The MySQL Native Driver Plugin API is a feature of MySQL Native
  Driver, or mysqlnd. Mysqlnd
  plugins operate in the layer between PHP applications and the MySQL
  server. This is comparable to MySQL Proxy. MySQL Proxy operates on a
  layer between any MySQL client application, for example, a PHP
  application and, the MySQL server. Mysqlnd plugins
  can undertake typical MySQL Proxy tasks such as load balancing,
  monitoring and performance optimizations. Due to the different
  architecture and location, mysqlnd plugins do not
  have some of MySQL Proxy's disadvantages. For example, with plugins,
  there is no single point of failure, no dedicated proxy server to
  deploy, and no new programming language to learn (Lua).
 
  A mysqlnd plugin can be thought of as an extension
  to mysqlnd. Plugins can intercept the majority of
  mysqlnd functions. The mysqlnd
  functions are called by the PHP MySQL extensions such as
  ext/mysql, ext/mysqli, and
  PDO_MYSQL. As a result, it is possible for a
  mysqlnd plugin to intercept all calls made to these
  extensions from the client application.
 
  Internal mysqlnd function calls can also be
  intercepted, or replaced. There are no restrictions on manipulating
  mysqlnd internal function tables. It is possible to
  set things up so that when certain mysqlnd
  functions are called by the extensions that use
  mysqlnd, the call is directed to the appropriate
  function in the mysqlnd plugin. The ability to
  manipulate mysqlnd internal function tables in this
  way allows maximum flexibility for plugins.
 
  Mysqlnd plugins are in fact PHP Extensions, written
  in C, that use the mysqlnd plugin API (which is
  built into MySQL Native Driver, mysqlnd). Plugins
  can be made 100% transparent to PHP applications. No application
  changes are needed because plugins operate on a different layer. The
  mysqlnd plugin can be thought of as operating in a
  layer below mysqlnd.
 
  The following list represents some possible applications of
  mysqlnd plugins.
 
Load Balancing
Read/Write Splitting. An example of this is the PECL/mysqlnd_ms (Master Slave) extension. This extension splits read/write queries for a replication setup.
Failover
Round-Robin, least loaded
Monitoring
Query Logging
Query Analysis
Query Auditing. An example of this is the PECL/mysqlnd_sip (SQL Injection Protection) extension. This extension inspects queries and executes only those that are allowed according to a ruleset.
Performance
Caching. An example of this is the PECL/mysqlnd_qc (Query Cache) extension.
Throttling
Sharding. An example of this is the PECL/mysqlnd_mc (Multi Connect) extension. This extension will attempt to split a SELECT statement into n-parts, using SELECT ... LIMIT part_1, SELECT LIMIT part_n. It sends the queries to distinct MySQL servers and merges the result at the client.
MySQL Native Driver Plugins Available
There are a number of mysqlnd plugins already available. These include:
PECL/mysqlnd_mc - Multi Connect plugin.
PECL/mysqlnd_ms - Master Slave plugin.
PECL/mysqlnd_qc - Query Cache plugin.
PECL/mysqlnd_pscache - Prepared Statement Handle Cache plugin.
PECL/mysqlnd_sip - SQL Injection Protection plugin.
PECL/mysqlnd_uh - User Handler plugin.
